The scientists from UT Southwestern have resolved how circulating “bad cholesterol” goes into artery walls to induce the plaque that channels the blood vessels and causes strokes and heart attacks. Since LDL (low-density lipoprotein), cholesterol entry in the artery wall impels the progression of atherosclerosis—or toughening of the arteries—and atherosclerosis causes heart attacks and strokes. The future therapies preventing the procedure might aid in decreasing the incidence of these life-threatening medical conditions, stated senior author of the study Dr. Philip Shaul. The study was published in Nature.
Reportedly, CVD (cardiovascular disease) is the number one reason of death globally and coronary artery disease—which pervades heart attacks and strokes—accounts for more than 60% of CVD deaths in the U.S., as per to new statistics from the AHA (American Heart Association). For the first time, the study disclosed how a protein known as SR-B1 (scavenger receptor class B, type 1) carries LDL particles into and then toward endothelial cells that channels arteries. The study also discovered that a second protein is known as DOCK4 (dedicator of cytokinesis 4) links with SR-B1 and is required for the process. During the early phases of atherosclerosis, LDL that has joined the artery wall draws and is surrounded by significant immune system cells known as macrophages that ingest or consume LDL particles.
On a similar note, recently, the study showed that by unblocking arteries following a heart attack might be lifesaving for older patients. Amongst heart attack patients—who are 75 Years and older—the oldest of those patients were less expected than younger patients to get an operation to open blocked arteries. But, the older patients were more apt to survive heart attacks if they underwent the procedure known as PCI (percutaneous coronary intervention), as per to new research. The research was published in Circulation: Cardiovascular Interventions, which is an AHA journal.
Cindy has studied Genetic Engineering from one of the top universities across the country and is a certified medical coder. She writes on human health care and medical domain. She is associated with us from the beginning of our portal and currently, working is Content Writer. Cindy is an avid reader and likes to read novels, autobiographies, thrillers, and graphic novel. Cindy believes in staying healthy and so after the office spends her time in the gym on functional training.